Axial and Rotational Malreduction (Golf Club Deformity) in Distal Femur Fractures.

OBJECTIVES: To describe malreduction of supracondylar distal femur fractures stabilized with lateral femoral locking plates and determine whether a mismatch in axial lateral distal femur anatomy and lateral distal femoral plate design contributes to supracondylar distal femoral fracture malreduction. MATERIALS AND METHODS: OTA/AO 33A were simulated in 7 cadaver femurs and fixed with a lateral distal locking femoral plate placed flush to the lateral femoral condyle (group 1). In group 2, the anterior flange of the plate was externally rotated 10 degrees in relation to the lateral condyle. A motion capture system measured translation and rotation of the articular segment as shaft screws were applied, reducing plate to femoral diaphysis. Articular segment movement was compared between groups using paired Student t test, P < 0.05. A large database of 3D scans of 800 femurs was used to define the relationship of the lateral femoral condyle to the lateral cortical surface of the human femur. RESULTS: Malreduction was observed with anatomic plate application results from medial translation (17 mm) and external rotation (12.2 degrees) (group 1). Modifying plate geometry to match lateral femur anatomy (group 2) improved medial translation by 46% and external rotation by 80%. An analysis of the shape of the 800 distal femurs showed that the average posterior anterior inclination is 16.5 degrees. CONCLUSIONS: Anatomic application of distal femoral plates results in significant malreduction. Modifying the plate design to accommodate 10 degrees slope of lateral distal femur results in partial correction of deformity. Future studies should investigate other means of correcting the malalignment, especially considering the 16.5-degree posterior anterior inclination of the condyle.

Does coating an intramedullary nail with polymethylmethacrylate improve mechanical stability at the fracture site?

BACKGROUND: Treatment of tibia diaphyseal fractures with intramedullary nail fixation has proven to be effective. An increasingly popular practice is to coat the nail with bone cement incorporating antibiotics for the purpose of treating and/or preventing infection. To date, the effect of coating on the mechanical performance of the intramedullary nail once implanted is unknown. We hypothesize that cement coating does not change the cross-sectional stiffness of the nail, so that, when fixing tibia diaphyseal fracture with gapping, cement coated intramedullary nail provide stiffness comparable to that of standard conventional uncoated ones. METHODS: Tests of 4-point bending were conducted to compare the cross-sectional stiffness of uncoated to coated nails. In addition, mechanical tests of compression and torsion on tibia bone phantoms instrumented with coated and uncoated nails were performed, and the proximal-to-distal bone fragment rotations were compared. FINDINGS: The 4-point bending tests indicated that the cross-sectional stiffness of coated nails was not significantly different from that of the uncoated ones (p-value >0.05). Mechanical tests of compression and torsion corroborated these results by showing no statistical difference in the proximal-to-distal bone rotations attained with uncoated nails when compared to those measured for the coated ones (p-value >0.05). INTERPRETATION: Cement coating on the nail cannot be relied upon for increased mechanical stiffness of the implant, and should be solely considered as a vehicle for topic delivery of antibiotics.

Mechanical performance and implications on bone healing of different screw configurations for plate fixation of diaphyseal tibia fractures: a computational study.

Diaphyseal tibia fractures may require plate fixation for proper healing to occur. Currently, there is no consensus on the number of screws required for proper fixation or the optimal placement of the screws within the plate. Mechanical stability of the construct is a leading criterion for choosing plate and screws configuration. However, number and location of screws have implications on the mechanical environment at the fracture site and, consequently, on bone healing response: The interfragmentary motion attained with a specific plate and screw construct may elicit mechano-transduction signals influencing cell-type differentiation, which in turn affects how well the fracture heals. This study investigated how different screw configurations affect mechanical performance of a tibia plate fixation construct. Three configurations of an eight-hole plate were considered with the fracture in the center of the plate: eight screws-screws at first, fourth, fifth and eighth hole and screws at first, third, sixth and eighth hole. Constructs' stiffness was compared through biomechanical tests on bone surrogates. A finite element model of tibia diaphyseal fracture was used to conduct a stress analysis on the implanted hardware. Finally, the potential for bone regeneration of each screw configuration was assessed via the computational model through the evaluation of the magnitude of mechano-transduction signals at the bone callus. The results of this study indicate that having screws at fourth and fifth holes represents a preferable configuration since it provides mechanical properties similar to those attained by the stiffest construct (eight screws), and elicits an ideal bone regenerative response.

A novel way to dynamize a spatial frame and optimize fracture healing.

BACKGROUND: Fracture site motion creates mechanical strains on the healing tissues which influences bone formation. Axial micro-motion maximizes dilatational strains, whereas shearing motions maximize deviatoric strains on the healing tissues. Dilatational strains optimize bone healing, deviatoric strains retard bone healing. Dynamization of external fixation using either an Ilizarov or Spatial Frame platform is used to increase loading on the limb which increases the mechanical stress and strain on the tissues to improve healing. The scientific literature does not address how dynamization of the spatial frame effects fracture site motion. The purpose of this study is to assess the effect of modified shoulder bolts incorporated into a spatial frame during dynamic loading. METHODS: Five identical two-ring spatial frame constructed were mounted on Sawbones tibias with an osteotomy performed distal to the tibial tubercle. Sinusoidal load was applied at a rate of 0.25 Hz. Axial force and displacement, in addition to motion of the proximal and distal tibia segments were recorded. Eight constructs were tested: 1) All struts of the Spatial Frame rigid, 2) Strut #1 loose, 3) Struts #1 and #3 loose, 4) Struts #1, #3 and #5 loose, 5) All struts loose, 6) All struts rigid with dynamization bolts on the proximal end, 7) All struts rigid with dynamization bolts on alternating sides, 8) Threaded rods between the rings with two millimeters of dynamization. RESULTS: No difference in vertical displacement was observed between the Ilizarov and all struts locked. No significant difference in shear values between all struts locked and modified shoulder bolt struts was observed. Increase in vertical movement with the modified shoulder bolts was an average of 1.83 mm. Significant shear forces at the fracture site were observed with unlocking single or multiple struts of the spatial frame. CONCLUSION: Modified shoulder bolts can be used for spatial frame dynamization without increasing shear motion.

Effects of Lumbosacral Arthrodesis on the Biomechanics of the Sacroiliac Joint.

BACKGROUND: It is unclear whether the sacroiliac joint is vulnerable to adjacent segment disease. Clinical studies have suggested that many patients who have undergone lumbar arthrodesis will develop adjacent segment disease, which may contribute to sacroiliac joint degeneration. The purpose of the present study was to examine whether arthrodesis in the lumbar spine results in altered biomechanics at the sacroiliac joint that could contribute to adjacent segment disease within the joint. METHODS: With use of human cadavers in a biomechanical laboratory study, the effects of lower-lumbar arthrodesis and sacroiliac screws on the biomechanics of the sacroiliac joint were assessed. Human cadaveric pelves with lumbar spines were biomechanically tested in flexion-extension, rotation about the vertical axis, and compression along the vertical axis with single and double-leg support. Four conditions were compared: (1) intact, (2) L4-L5 arthrodesis, (3) L4-S1 arthrodesis, and (4) left sacroiliac screw. Construct vertical and horizontal motions at the anterior and posterior surfaces of the sacroiliac joint were measured. RESULTS: Significant measurable increases in motion of the sacroiliac joint related to arthrodesis of the lumbar spine occurred with flexion-extension loading (p < 0.05). No significant changes were observed for rotation about the vertical axis or compression along the vertical axis with single and double-leg support. CONCLUSIONS: After 360°, 1 or 2-level lumbosacral spine arthrodesis, the sacroiliac joint showed a significant increase in rotational motion with flexion-extension loading. Increases in horizontal translation with axial rotation loading and vertical translation with axial compression loading were not significant. CLINICAL RELEVANCE: The risk of significant alteration of normal sacroiliac kinematics should be considered in all patients undergoing 360° lumbosacral arthrodesis.

Comparison of Biomechanical Properties of a Synthetic L3-S1 Spine Model and Cadaveric Human Samples.

Human cadavers currently represent the gold standard for spine biomechanical testing, but limitations such as costs, storage, handling, and high interspecimen variance motivate the development of alternatives. A commercially available synthetic surrogate for the human spine, the Sawbones spine model (SBSM), has been developed. The equivalence of SBSM to a human cadaver in terms of biomechanical behavior has not been fully assessed. The objective of this study is to compare the biomechanics of a lumbar tract of SBSM to that of a cadaver under physiologically relevant mechanical loads. An L3-S1 SBSM and 39 comparable human cadaver lumbar spine tracts were used. Each sample was loaded in pure flexion-extension or torsion. Gravity and follower loads were also included. The movement of each vertebral body was tracked via motion capture. The range of motion (ROM) of each spine segment was recorded, as well as the overall stiffness of each L3-S1 sample. The ROM of SBSM L3-L4 was larger than that found in cadavers in flexion-extension and torsion. For the other spine levels, the ROMs of SBSM were within one standard deviation from the mean values measured in cadavers. The values of structural stiffness for L3-S1 of SBSM were comparable to those of cadaveric specimens for both flexion and torsion. In extension, SBSM was more compliant than cadavers. In conclusion, most of the biomechanical properties of an L3-S1 SBSM model were comparable to those of human cadaveric specimens, supporting the use of this synthetic surrogate for testing applications.

Biomechanical Comparison between Volar Plate Fixator and Nonbridge External Wrist Fixator.

Intra-articular distal radius fractures are difficult to reduce and maintain by nonoperative means. ORIF leaves implants in the patient long after the fracture is healed. External fixation can stabilize the reduced fracture and leaves no long-term implants. The nonbridging fixator (NBX) will provide better reduction and comparable rigidity of fixation to a volar plate for a 5-fragment, OTA 23 C3.2 distal radius fracture. A 5-part distal radius fracture was created in 5 pairs of cadaver arms. One arm was randomly fixed with the NBX fixator; the matched pair was fixed with a volar plate (VPS). Fluoroscopic images recorded the extremes of passive volar-dorsiflexion range of motion (ROM) and radial-ulnar deviation ROM. Each arm was loaded with an axial force at a constant displacement rate until failure. The average reduction of radial tilt achieved for the NBX group was 13.8 ± 4.8° and 6.3 ± 4.7° for VPS; radial length: 3.4 ± 3.7 mm for NBX and 1.9 ± 1.0 mm for VPS; volar tilt: 26.3 ± 12.4° for NBX and 14.0 ± 13.5° for VPS. For NBX, ROM was slightly less after fixation than before fracture. ROM with volar plating was greater after fracture. The peak axial load for NBX was 925 ± 445 N; for VPS, 2,152 ± 1023 N. NBX had minimal effect on ROM and provided adequate strength and restoration of alignment at least as good as VPS for this 5-part fracture model.

Cerclage Cable Tensioning of Intraoperative Hip Arthroplasty Proximal Femoral Fractures: A Cadaveric Model.

Cerclage fixation following intraoperative fracture of the proximal femur during total hip arthroplasty (THA) carries a risk of compromising the femoral blood supply. Thus, we sought to determine the minimum cerclage cable tension required to restore the stability of a cementless femoral stem. Cementless femoral prostheses were implanted in seven proximal femoral cadaver specimens, and a periprosthetic fracture was simulated in the medial cortex. A single cerclage cable was placed just above the lesser trochanter and tensioned and tested at increasing intervals. The implant's torsional stability was determined in the intact bone, prior to fixation, and at each level of cable tension. We found that a single cerclage cable placed above the lesser trochanter can significantly improve, but not fully restore, torsional stability following intraoperative periprosthetic femur fracture during THA. The optimal position for a single cerclage cable appears to be above the lesser trochanter. (Journal of Surgical Orthopaedic Advances 29(4):209-211, 2020).

Supplemental Fixation of Inner Graft Limbs in All-Inside, Quadrupled, Single-Tendon Anterior Cruciate Ligament Reconstruction Graft Construct Yields Improved Biomechanical Properties.

PURPOSE: To compare the time-zero load to failure of a quadrupled, single-tendon, all-inside anterior cruciate ligament (ACL) reconstruction graft construct with (supplemented) and without the incorporation of inner-limb whipstitch sutures (control) into a tibial suspensory fixation button. METHODS: Eight matched pairs of peroneus longus tendons were prepared according to a quadrupled, all-inside ACL soft-tissue graft technique with 1 side serving as a control and the contralateral side supplemented. The constructs were biomechanically tested for strain in the inner and outer limbs during a preconditioning protocol, single-cycle load to failure, and elongation of the whole construct. RESULTS: Ultimate load to failure was significantly higher in the supplemented group: 797.5 ± 49.6 N (95% confidence interval [CI], 763.13-831.87 N) versus 719.6 ± 69.6 N (95% CI, 671.38-767.82 N; P = .044). Less graft elongation at failure was observed in the supplemented group (3.1 ± 1.5 mm; 95% CI, 2.07-4.17 mm) versus the control group (21.0 ± 21.2 mm; 95% CI, 6.31-35.69 mm; P = .052). The number of grafts undergoing a 5-mm or greater change in length at failure was 1 of 8 in the supplemented group versus 5 of 8 in the control group (P = .038). CONCLUSIONS: Inner-limb supplemental tibial fixation results in higher time-zero load to failure and decreased graft elongation in a quadrupled, single-tendon, all-inside ACL reconstruction graft construct. CLINICAL RELEVANCE: The weak point of a single-tendon, quadrupled, all-inside ACL graft construct is the tendon-to-tendon suturing to secure the inner limbs of the graft. Adding supplemental fixation by incorporating the sutures from the inner limb to the tibial suspensory fixation button leads to a higher time-zero load to failure and decreased graft elongation.

Effects of gamma irradiation on the biomechanical properties of peroneus tendons.

PURPOSE: This study was designed to investigate the biomechanical properties of nonirradiated (NI) and irradiated (IR) peroneus tendons to determine if they would be suitable allografts, in regards to biomechanical properties, for anterior cruciate ligament reconstruction after a dose of 1.5-2.5 Mrad. METHODS: Seven pairs of peroneus longus (PL) and ten pairs of peroneus brevis (PB) tendons were procured from human cadavers. The diameter of each allograft was measured. The left side of each allograft was IR at 1.5-2.5 Mrad, whereas the right side was kept aseptic and NI. The allografts were thawed, kept wet with saline, and attached in a single-strand fashion to custom freeze grips using liquid nitrogen. A preload of 10 N was then applied and, after it had reached steady state, the allografts were pulled at 4 cm/sec. The parameters recorded were the displacement and force. RESULTS: The elongation at the peak load was 10.3±2.3 mm for the PB NI side and 13.5±3.3 mm for the PB IR side. The elongation at the peak load was 17.4±5.3 mm for the PL NI side and 16.3±2.0 mm for the PL IR side. For PL, the ultimate load was 2,091.6±148.7 N for NI and 2,122.8±380.0 N for IR. The ultimate load for the PB tendons was 1,485.7±209.3 N for NI and 1,318.4±296.9 N for the IR group. The ultimate stress calculations for PL were 90.3±11.3 MPa for NI and 94.8±21.0 MPa for IR. For the PB, the ultimate stress was 82.4±19.0 MPa for NI and 72.5±16.6 MPa for the IR group. The structural stiffness was 216.1±59.0 N/mm for the NI PL and 195.7±51.4 N/mm for the IR side. None of these measures were significantly different between the NI and IR groups. The structural stiffness was 232.1±45.7 N/mm for the NI PB and 161.9±74.0 N/mm for the IR side, and this was the only statistically significant difference found in this study (P=0.034). CONCLUSION: Our statistical comparisons found no significant differences in terms of elongation, ultimate load, or ultimate stress between IR and NI PB and PL tendons. Only the PB structural stiffness was affected by irradiation. Thus, sterilizing allografts at 1.5-2.5 Mrad of gamma irradiation does not cause major alterations in the tendons' biomechanical properties while still providing a suitable amount of sterilization for anterior cruciate ligament reconstruction.

Biomechanical Analysis of All-Inside, Arthroscopic Suture Repair Versus Extensor Retinaculum Capsulorrhaphy for Triangular Fibrocartilage Complex Tears With Instability.

PURPOSE: To assess ulnocarpal joint stability after treatment of a peripheral triangular fibrocartilage complex (TFCC) injury with all-inside arthroscopic suture repair (SR), extensor retinaculum capsulorrhaphy with the Herbert sling (HS), and a combination of both (SR+HS). METHODS: Twelve fresh-frozen, age-matched, upper-extremity specimens intact from the distal humerus were prepared. Nondestructive mechanical testing was performed to assess native ulnocarpal joint stability and load-displacement curves were recorded. A peripheral, ulnar-sided TFCC injury was created with arthroscopic assistance, and mechanical testing was performed. Each specimen was treated with SR or HS and testing was repeated. The 6 specimens treated with SR were then treated with HS (SR+HS), and testing was repeated. We used paired Student t tests for statistical analysis within cohorts. RESULTS: For all cohorts, there was an average increase in ulnar translation after the creation of a peripheral TFCC injury and an average decrease after repair. Herbert sling decreased translation by 21%, SR decreased translation by 12%, and SR+HS decreased translation by 26%. CONCLUSIONS: Suture repair plus HS and HS reduce ulnar translation the most after a peripheral TFCC injury, followed by SR alone. CLINICAL RELEVANCE: Ulnocarpal joint stability should be assessed clinically in patients with peripheral TFCC injury, and consideration should be made for using extensor capsulorrhaphy in isolation or as an adjunct to SR as a treatment option.

Biomechanical evaluation of periprosthetic refractures following distal femur locking plate fixation.

INTRODUCTION: Distal femur fractures proximal to total knee femoral component constitutes the most prevalent type of periprosthetic fracture, and plate fixation treatment is associated with a 7.7% incidence of refracture proximal to the plate. The primary objective of this study was to compare proximal fixation techniques of a periprosthetic distal femur fracture plate in an osteoporotic bone model. The secondary objective was to determine the subsequent periprosthetic plate fracture pattern and/or complexity associated with each proximal plate fixation configuration. MATERIALS AND METHODS: A segmental defect was created in 21 synthetic osteoporotic adult femurs 6 cm proximal to the distal femur and all specimens were stabilised with a 246 mm locking femur plate. Fixation in the most proximal hole was varied by use of either a cerclage cable, unicortical locking screw, or a bicortical locking screw. Specimens were tested to failure in simultaneous eccentric compression and torsion. RESULTS: Proximal cerclage fixation demonstrated higher mean maximum axial force at failure (4142.67±178.71 N, p<0.001), stiffness (443.8±61.64 N/mm), and maximum torque (20.9±0.93 N m, p<0.001). Unicortical and bicortical screw refractures occurred at the screw, cerclage wire refractures occurred at the first proximal screw distal to the cerclage. CONCLUSIONS: In periprosthetic distal femur fracture locking plate fixation, proximal hole stabilization with a cerclage wire tolerates significantly higher failure forces while distributing forces distal to the area within the plate fixation. Cerclage wiring may be an option in distal femur periprosthetic fractures to alleviate stress risers in vulnerable bone.

Biomechanical analysis of four- versus six-screw constructs for short-segment pedicle screw and rod instrumentation of unstable thoracolumbar fractures.

BACKGROUND CONTEXT: Conventionally, short-segment fusion involves instrumentation of one healthy vertebra above and below the injured vertebra, skipping the injured level. This short-segment construct places less surgical burden on the patient compared with long-segment constructs, but is less stable biomechanically, and thus has resulted in clinical failures. The addition of two screws placed in the fractured vertebral body represents an attempt to improve the construct stiffness without sacrificing the benefits of short-segment fusion. PURPOSE: To determine the biomechanical differences between four- and six-screw short-segment constructs for the operative management of an unstable L1 fracture. STUDY DESIGN: Biomechanical study of instrumentation in vertebral body cadaveric models simulating an L1 axial load injury pattern. METHODS: Thirteen intact spinal segments from T12 to L2 were prepared from fresh-frozen cadaver spines. An axial load fracture of at least 50% vertebral body height was produced at L1 and then instrumented with pedicle screws. Specimens were evaluated in terms of construct stiffness, motion, and rod strain. Two conditions were tested: a four-screw construct with no screws at the L1 fractured body (4S) and a six-screw construct with screws at all levels (6S). The two groups were compared statistically by paired Student t test. RESULTS: The mean stiffness in flexion-extension was increased 31% (p<.03) with the addition of the two pedicle screws in L1. Relative motion in terms of vertical and axial rotations was not significantly different between the two groups. The L1-L2 rod strain was significantly increased in the six-screw construct compared with the four-screw construct (p<.001). CONCLUSIONS: In a cadaveric L1 axial load fracture model, a six-screw construct with screws in the fractured level is more rigid than a four-screw construct that skips the injured vertebral body.

Peripheral triangular fibrocartilage complex tears cause ulnocarpal instability: a biomechanical pilot study.

BACKGROUND: Instability at the ulnocarpal joint has many causes, but the common thread among these causes is the presence of abnormalities in the triangular fibrocartilage complex (TFCC). However, the biomechanical consequences at the ulnocarpal joint after detachment of the TFCC from the ulnar styloid are not clearly defined. Better delineation of whether peripheral TFCC detachments cause ulnocarpal instability will help to design surgical treatments. QUESTIONS/PURPOSES: We asked whether detachment of the peripheral TFCC from the ulnar styloid causes ulnocarpal instability. METHODS: Using 20 fresh-frozen below-elbow cadaver specimens, the distal ulna was cycled volarly and dorsally with the carpus held firmly. The load-displacement curve was analyzed to determine the resistance of the ulnocarpal joint against dorsal-volar displacement of the ulna (stiffness) and the amount of dorsal-volar excursion with minimal resistance before reaching firm end points dorsally and volarly. A standardized 3-mm transection of the attachment of the TFCC from the ulnar styloid was created with a scalpel using arthroscopic observation. Mechanical testing was repeated and paired Student's t-tests conducted. RESULTS: The mean stiffness of the ulnocarpal joint was decreased after detachment. The amount of dorsal-volar excursion was similar after detachment of the peripheral TFCC. CONCLUSIONS: There is decreased stiffness at the ulnocarpal joint after detachment of the peripheral TFCC, but there is no biomechanically detectable difference in dorsal-volar excursion. CLINICAL RELEVANCE: The findings of the current study can be used to develop and evaluate innovative surgical techniques, such as capsulorraphy or ligamentous reconstruction, that specifically address laxity at the ulnocarpal joint after peripheral TFCC detachment.

Comparison of 2 forearm reconstructions for longitudinal radioulnar dissociation: a cadaver study.

PURPOSE: We present the results of a cadaveric study of 2 forearm reconstructions with radial head replacement for longitudinal radioulnar dissociation injuries. METHODS: We created a simulated longitudinal radioulnar dissociation injury in 8 cadaver forearms. Two reconstructions were performed alternately on each arm: patellar tendon interosseous ligament complex reconstruction and the Herbert sling extensor retinaculum plication. We performed mechanical testing in a materials testing machine with and without a radial head replacement, and measured ulnocarpal impaction force through 2 distal ulna strain gauges. We determined relative radioulnar displacement using live fluoroscopic analysis of implanted stainless-steel beads. RESULTS: Relative radioulnar longitudinal displacement in the destabilized forearms was 10.7 compared with 0.7 mm before creating the injury. A prosthetic radial head replacement alone decreased the displacement by 75% to 2.7 mm. Interosseous ligament reconstruction alone reduced the displacement to 5.1 mm and to 1.3 mm when combined with a radial head implant. The Herbert sling alone did not improve longitudinal stability. The distal ulna force in the native arm was 17 N, or 17% of the force across the wrist. The interosseous ligament reconstruction restored the force to 21 N, whereas the Herbert sling only marginally decreased the ulna impaction force to 45 N. Adding a radial head decreased the distal ulna force to 7 N for the patellar tendon interosseous ligament reconstruction, and 2 N for the Herbert sling. CONCLUSIONS: In longitudinal radioulnar dissociation injuries, the radial head is an important stabilizer and should be repaired or replaced to minimize radial shortening and ulnar impaction force. Patellar tendon interosseous ligament reconstruction effectively restores the ulnocarpal force distribution and markedly reduces longitudinal instability at the distal radioulnar joint. Combined with radial head arthroplasty, the construct has stability similar to an intact forearm. The Herbert sling did not improve longitudinal stability in this testing construct. CLINICAL RELEVANCE: Treatment of longitudinal radioulnar dissociation may benefit from radial head replacement and interosseous ligament reconstruction using a patellar tendon graft.

Adjacent-level biomechanics after single versus multilevel cervical spine fusion.

OBJECT: Previous studies have demonstrated that patients with spinal fusion are at greater risk for adjacent-segment disease and require additional surgery. It has been postulated that excessive motion of a given motion segment unit (MSU) leads to an increased risk of disc degeneration. It is the authors' hypothesis that a greater increase in adjacent-segment motion will be observed following a 2-level versus a single-level anterior cervical discectomy and instrumented fusion (ACDF). Therefore, they undertook this study to determine the effect of single-level versus 2-level ACDF on the biomechanics of adjacent MSUs. METHODS: Ten fresh-frozen human cervical spines were used in this study. The specimens were potted at C-4 and T-1 and tested in flexion and extension. Range of motion (ROM) was 30° of flexion and 15° of extension at a maximum load of 50 N. The specimens were tested intact and then were randomized into 2 groups of 5 specimens each. Group 1 underwent a single-level ACDF at the C5-6 level first, and Group 2 underwent the procedure at the C6-7 level. After testing, both groups had the fusion extended to include the C5-7 levels, and the testing was repeated. Changes in overall ROM, stiffness, and segmental motion were calculated and statistically analyzed using a paired Student t-test. RESULTS: An increase in sagittal ROM of 31.30% above (p = 0.012) and 33.88% below (p = 0.066) the fused MSU was found comparing a 2-level with a 1-level ACDF. The overall stiffness of the entire spinal construct increased 37.34% (p = 0.051) in extension and 30.59% (p = 0.013) in flexion as the second fusion level was added. As expected, the overall sagittal ROM of the entire spinal construct decreased by 13.68% (p = 0.0014) with a 2-level compared with a 1-level fusion. CONCLUSIONS: This study has shown that the biomechanics at adjacent levels to a cervical spine fusion are altered and that there is increased adjacent-segment motion at the levels above and below, after a 2-level compared with a 1-level ACDF.

Building a biomechanical model.

This article is based on an invited presentation at the Biomechanics Session for the Basic Science Focus Forum held at the Orthopaedic Trauma Association meeting, 2010. It is not intended to be a scientific presentation of any specific investigation. It presented aspects of several types of investigations to illustrate the variety of biomechanical models that are used, and what value can be derived from those models. All models have limitations in what they try to portray. In order for any model to provide useful information, it must stand some type of validation of its ability to behave similar to real world experiences. The advantages and disadvantages of each model must be described to the best of the investigators ability-so that the readers can determine how the information may be used in the real world.

The efficacy of cylindrical titanium mesh cage for the reconstruction of a critical-size canine segmental femoral diaphyseal defect.

The authors developed a novel technique for the reconstruction of large segmental long bone defects using a cylindrical titanium mesh cage (CTMC). Although the initial clinical reports have been favorable, the CTMC technique has yet to be validated in a clinically relevant large animal model, which is the purpose of this study. Under general anesthesia, a unilateral, 3-cm mid-diaphyseal segmental defect was created in the femur of an adult canine. The defect reconstruction technique consisted of a CTMC that was packed and surrounded with a standard volume of morselized canine cancellous allograft and canine demineralized bone matrix. The limb was stabilized with a reamed titanium intramedullary nail. Animals were distributed into four experimental groups: in Groups A, B, and C (six dogs each), defects were CTMC reconstructed, and the animals euthanized at 6, 12, and 18 weeks, respectively; in Group D (three dogs), the same defect reconstruction was performed but without a CTMC, and the animals were euthanized at 18 weeks. The femurs were harvested and analyzed by gross inspection, plain radiography, computed tomography (CT), and single photon emission computed tomography (SPECT). The femurs were mechanically tested in axial torsion to failure; two randomly selected defect femurs from each group were analyzed histologically. Groups A, B, and C specimens gross inspection, plain radiography, and CT, demonstrated bony restoration of the defect, and SPECT confirmed sustained biological activity throughout the CTMC. Compared to the contralateral femur, the 6-, 12-, and 18-week mean defect torsional stiffness was 44.4, 45.7, and 72.5%, respectively; the mean torsional strength was 51.0, 73.6, and 83.4%, respectively. Histology documented new bone formation spanning the defect. Conversely, Group D specimens (without CTMC) demonstrated no meaningful bone formation, biologic activity, or mechanical integrity at 18 weeks. The CTMC technique facilitated healing of a canine femur segmental defect model, while the same technique without a cage did not. The CTMC technique may be a viable alternative for the treatment of segmental long bone defects.

The role of soft tissues in plate fixation of proximal phalanx fractures.

The tension band effect of plate fixation and the contribution of soft tissues to that effect was examined biomechanically in human proximal phalanges. Forty-six proximal phalanges in whole cadaver hands with all soft tissues in place (intact) and 43 proximal phalanges stripped of soft tissues (denuded) were tested. After midshaft osteotomy, each proximal phalanx was fixed internally with a dorsal minicondylar plate, a lateral minicondylar plate, a dorsal straight plate, or a lateral straight plate. Specimens were tested in three-point apex dorsal bending to clinical failure, defined as 30 degrees angulation. Ultimate moment (stability) at this angulation was similar among the four fixation methods in the specimens with all soft tissues intact. Stability also was similar among these methods in the denuded specimens. There were no significant differences in stability between minicondylar and straight plates or between dorsal and lateral plates in the specimens with soft tissues, nor were there significant differences between these groups in the denuded specimens. The stability of the four fixation methods was significantly greater in the specimens with soft tissues than in the denuded specimens. Soft tissues increased the stability of lateral minicondylar plates by 163%, lateral straight plates by 157%, dorsal minicondylar plates by 126%, and dorsal straight plates by 104%, providing a dorsal tension band effect that counteracted the buttress (compression) of the volar fracture surfaces of the phalanx. The results suggest that in the clinical setting a laterally placed straight or minicondylar plate may provide as much stability to a phalanx with a midshaft fracture as does the traditional, more invasive dorsally placed minicondylar or straight plate. These findings must be evaluated with caution, however, because all specimens were from embalmed cadavers, and the formalin fixation may have augmented the stability and stiffness of the soft tissues in the intact specimens. A subsequent pilot study comparing intact proximal phalangeal specimens that were formalin-fixed with those that were fresh-frozen showed a significant increase in stability and stiffness of formalin-fixed specimens.

Role of soft tissues in metacarpal fracture fixation.

The contribution of soft tissues in stabilizing fracture fixation in metacarpals is appreciated clinically, but no quantitative biomechanical study of their role has been done. All previous studies of fracture fixation in vitro have been done on metacarpals denuded of soft tissues. To quantify the role of soft tissues in metacarpal fracture fixation, the biomechanical effectiveness of four fixation devices was examined in human cadaver metacarpals with and without soft tissues. Values were compared for three nonrigid methods (expandable intramedullary fixation devices, crossed Kirschner wires, and single half-pin frames) and one rigid method (dorsal plates) in 45 disarticulated metacarpals stripped of soft tissues (denuded) and in 46 metacarpals in whole hands with all soft tissues remaining (intact). Mechanical testing to complete failure in three-point apex dorsal bending was done in all specimens. Ultimate moment (strength) of each of the four fixation methods was significantly greater in intact specimens than in denuded specimens. Crossed Kirschner wires were most stable in intact specimens, and dorsal plates were more stable in denuded specimens. The results show that soft tissues contribute to the strength of fracture fixation. Clinically, surgeons may be able to use a less invasive fixation method than plating without compromising the strength of metacarpal fixation in patients whose soft tissues are not severely disrupted and the fracture configuration allows. Plating may offer optimum stability in patients whose soft tissues are damaged severely and provide less strengthening of the fracture construct.